In a major breakthrough, scientists have been successful in developing the first lab-grown epidermis — the outermost skin layer — which could replace animals in drug and cosmetics testing.
The new epidermis, grown from human pluripotent stem cells (iPSC), could also help develop new therapies for rare and common skin disorders.
The research, done by King’s College London and the San Francisco Veteran Affairs Medical Center (SFVAMC), describes the use of human induced iPSC to produce an unlimited supply of pure keratinocytes — the predominant cell type in the outermost layer of skin.
This closely matches keratinocytes generated from human embryonic stem cells (hESC) and primary keratinocytes from skin biopsies.
The epidermis forms a protective interface between the body and its external environment. — IANS
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